In stock
$7.26 USD
Short description


Indomethacin belongs to the group of non-steroidal anti-inflammatory drugs and has important anti-inflammatory and analgesic properties similar to those of salicylates, since it is a potent inhibitor of cyclooxygenase, which is the prostaglandin-forming enzyme involved in the inflammatory process; it also inhibits the motility of polymorphonuclear leukocytes.

Indomethacin is rapidly and almost completely absorbed from the gastrointestinal tract after oral administration. The maximum plasma concentration is reached within two hours in the fasting subject, but it may be delayed when ingested after meals or it may be reduced by aluminum or magnesium contained in antacids. Plasma concentrations are around 0.5 µg / mL after prolonged administration. The plasma half-life has been reported to range from 2.6 to 11.2 hours in adults; it is bound to plasma proteins in 90% and also extensively in tissues. The concentration of indomethacin in the CNS is low, but within 5 hours of its administration its concentration in the synovial fluid is equal to that in plasma.

Indomethacin is metabolized in the liver to conjugated glocuronide and to desmethylindomethacin, desbenzoylindomethacin, desmethyl desbenzoylindomethacin, and their glucuronides; some indomethacin undergoes N-dealkylation. Indomethacin and its conjugates undergo enterohepatic circulation: Indomethacin excretion is mainly in the urine and to a lesser extent in the feces.

Betamethasone is a glucocorticoid with powerful activity, it has the general properties of glucocorticoids; 0.75 mg of betamethasone is equivalent in anti-inflammatory activity to about 5 mg of prednisolone. It is rapidly absorbed in the gastrointestinal tract and distributed to all tissues of the body.

Betamethasone binds to plasma proteins in greater amounts to globulin and in less amounts to albumin, which means that it has high affinity, but low binding capacity. It has a long half-life of 72 hours with an equivalent dose of 0.75 mg; it is metabolized in the liver and kidneys and is excreted in the urine. The effects of betamethasone on sodium and water are less than with prednisolone or prednisone.

Methocarbamol is a centrally acting muscle relaxant, whose mechanism of action is not established, but it is believed that it may be due to its general depressant effect on the CNS; it is rapidly and almost completely absorbed from the gastrointestinal tract after oral administration.

The effects start around half an hour after its administration. The plasma half-life is 1 to 2 hours.

Methocarbamol is used as an adjunct in the symptomatic treatment of painful muscle spasm associated with musculoskeletal disorders. It is metabolized by dealkylation and hydroxylation and is excreted primarily in the urine as glucuronide and sulfate conjugated to its metabolites. A small amount is excreted in the feces.

The analgesic effects resulting from the association of indomethacin, betamethasone and methocarbamol were tested in rats by the Pifir method and confirmed that the association of these compounds possess a very useful analgesic activity in arthritis conditions, since Indomethacin / Betamethasone / Methocarbamol showed analgesic efficacy superior to the compounds administered independently, its onset of action was faster with the association than with the compounds administered independently and with a longer duration of the analgesic effect, thus reducing the dosage of Indomethacin / Betamethasone / Methocarbamol the efficacy analgesic is sustained.

What shipping methods do you offer?
Currently there is only one shipping method available: regular airmail delivery (15-24 business days) via Mexican postal service, USPS, CANADA POST, and PARCEL FORCE.

Regular airmail is an inexpensive and reliable option.

Tracking information:
Please note that while regular airmail can also be tracked in most cases, the tracking information is available only on delivery (or attempted delivery) of the order. This allows us to see if your order was delivered successfully, but does not provide real-time delivery details.

What are your shipping rates and policies?
At the moment we offer 1 shipping option:

Regular Airmail Delivery (15-24 business days)
Once your order has been shipped, we will send you an email to notify you that your product has left our facilities. From this point on, your product is only 15-24 business days.

Please note that orders are shipped on business days only (Monday through Friday, excluding holidays).

You can view our shipping rate and other information after selecting a particular product.

Do you ship internationally?
In what currency is my purchase transaction received?
The currency used will be the US dollar.

How will my medication be packaged?
Your order will be properly packaged for your protection in transit to destination.

Where are the medications shipped from?
We ship from our office in Acapulco, Gro. Mexico

Where are the drugs you have to sell made?
Most of the drugs we offer are manufactured in Mexico, some are manufactured in countries such as Germany, England, France and others, all manufactured by large multinational laboratories legally established in Mexico.

What is the expiration date of the medications I receive?
We offer the guarantee that your product will have at least 10 months of use at the time of sale, however most of the drugs we sell have an expiration date greater than 1 to 2 years

What is your return policy?
Read the refund and cancellation policy

What forms of payment do you accept?
The payment options we have for clients are payments with a Credit or Debit card through:

We are unable to accept credit or debit card payments as VISA and Mastercard policies (do not allow pharmacies established outside the US to sell drugs to US customers).
How do I place an order?
When you click on an ADD TO CART link, you will be directed to our secure server where you will be registered as our customer. After selecting the required product and its quantity, you will be sent an email with the information of your purchase and the information to make the payment.

What happens once I send my order?
If your payment is received and identified, you will immediately receive an order confirmation email and another email once your order has been shipped.

How do I check the status of my order?
After making your purchase, you will receive an email with your order tracking information. This email contains information about the purchase and a link to the official pages of SEPOMEX, USPS, CANADA POST and PARCEL FORCE.

What is your security and privacy policy?
We are committed to protecting your privacy with the highest level of security possible. All your personal information, including name and address, is encrypted so that it cannot be read as it is transmitted from your computer to our server. We use the Secure Socket Layer (SSL) protocol which enables end-to-end data protection.